NeurosciencebioRxivPreprint
Selective Inhibition of Cytosolic PARylation via PARG99: A Targeted Approach for Mitigating FUS-associated Neurodegeneration
Manohar M. Kodavati, Vikas H. Maloji Rao, Joy Mitra, Muralidhar L. Hegde
This study investigates PARG99 as a cytosol-specific intervention to reduce FUS-associated toxicity in ALS models while preserving DNA repair.
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