Fructose-2,6-bisphosphate restores TDP-43 pathology-driven genome repair deficiency in motor neuron diseases
Anirban Chakraborty, Joy Mitra, Vikas H. Malojirao, Manohar M. Kodavati, Santi M. Mandal, Satkarjeet K. Gill, Sravan Gopalkrishnashetty Sreenivasmurthy, Velmarini Vasquez, Mikita Mankevich, Ludo Van Den Bosch, Ralph M. Garruto, Ian Robey, Balaji Krishnan, Gourisankar Ghosh, Muralidhar L. Hegde, Tapas K. Hazra
This study shows that fructose-2,6-bisphosphate (F2,6BP) restores genome repair and motor function in TDP-43 pathology-driven motor neuron diseases.
Communications Biology · Mar 10, 2026Peer-reviewedNeuroscience