Rewiring of RSK-PDZ interactions by linear motif phosphorylation
Gergő Gógl, Beáta Biri‐Kovács, Fabien Durbesson, Pau Jané, Yves Nominé, Camille Kostmann, Viktória Bilics, Márton A. Simon, Attila Reményi, Renaud Vincentelli, Gilles Travé, László Nyitray
The paper investigates how phosphorylation of a PDZ-binding linear motif alters interactions with PDZ domains, showing widespread modulation of binding affinities rather than discrete on/off switches.
bioRxiv · Sep 17, 2018 · PreprintSystems Biology