Yves Nominé

The Holdup Multiplex, an assay for high-throughput measurement of protein-ligand affinity constants using a mass-spectrometry readout

The paper introduces a high-throughput mass-spectrometry-based assay to measure protein-ligand affinity constants, demonstrating its application to 14-3-3 isoforms and phosphopeptides.

Quantitative fragmentomics allow affinity mapping of interactomes

The paper measures affinities of 65,000 PDZ domain interactions using quantitative fragmentomics, revealing viral interference hotspots and system-wide impacts of interactome hijacking.

ProFeatMap: a customizable tool for 2D feature representation of protein sets

ProFeatMap provides a customizable 2D visualization tool for protein features, enabling users to explore domain and modification information from a list of proteins.

Rewiring of RSK-PDZ interactions by linear motif phosphorylation

The paper investigates how phosphorylation of a PDZ-binding linear motif alters interactions with PDZ domains, showing widespread modulation of binding affinities rather than discrete on/off switches.