Gilles Travé

Structural analysis of HERC2/UBE3A and HERC2/DOCK10 complexes provides new insights into the molecular basis of Angelman, Angelman-like and Dup15q Syndromes

The paper analyzes the structural and functional interactions of HERC2/UBE3A and HERC2/DOCK10 complexes to understand their role in Angelman and Dup15q Syndromes.

A quantitative interactome map reveals affinity tailored hijacking of human cellular functions by resident and pathogenic bacteria

The paper reports a large-scale quantitative interactome of human PDZ domains and bacterial PDZ-binding motifs, showing bacteria tailor effector sequences to bind with similar or higher affinity than human PBMs to hijack host functions.

Interdependent androgen and glucocorticoid receptor signalling shapes prostate epithelial homeostasis

This study shows that glucocorticoid receptor (GR) interacts with androgen receptor (AR) to regulate prostate epithelial homeostasis through shared cis-regulatory elements.

Quantitative analysis of DNA-GATA1 binding alterations linked to hematopoietic disorders

This study quantifies how mutations in GATA1 affect DNA binding affinity using a new assay, revealing that certain mutations reduce binding while others increase it.

The Holdup Multiplex, an assay for high-throughput measurement of protein-ligand affinity constants using a mass-spectrometry readout

The paper introduces a high-throughput mass-spectrometry-based assay to measure protein-ligand affinity constants, demonstrating its application to 14-3-3 isoforms and phosphopeptides.

Comparative analysis of PDZ-binding motifs in the diacylglycerol kinase family

The paper identifies functional differences in PDZ-binding motifs among DGK enzyme types using interactomic and evolutionary analyses.

The human PDZome 2.0: characterization of a new resource to test for PDZ interactions by Yeast Two-Hybrid

The paper describes the development of PDZome 2.0, a Yeast Two-Hybrid resource for PDZ domain interactions, showing improved performance over the previous version using HPV16 E6 as a bait.

Native holdup (nHU) to measure binding affinities from cell extracts

The paper introduces nHU, a method to quantify binding affinities from cell extracts, showing agreement between in vitro and in-cell measurements.

Quantitative fragmentomics allow affinity mapping of interactomes

The paper measures affinities of 65,000 PDZ domain interactions using quantitative fragmentomics, revealing viral interference hotspots and system-wide impacts of interactome hijacking.

ProFeatMap: a customizable tool for 2D feature representation of protein sets

ProFeatMap provides a customizable 2D visualization tool for protein features, enabling users to explore domain and modification information from a list of proteins.

Rewiring of RSK-PDZ interactions by linear motif phosphorylation

The paper investigates how phosphorylation of a PDZ-binding linear motif alters interactions with PDZ domains, showing widespread modulation of binding affinities rather than discrete on/off switches.