The paper analyzes the structural and functional interactions of HERC2/UBE3A and HERC2/DOCK10 complexes to understand their role in Angelman and Dup15q Syndromes.

Nature Communications · Oct 31, 2026Peer-reviewedBiochemistry

The Holdup Multiplex, an assay for high-throughput measurement of protein-ligand affinity constants using a mass-spectrometry readout

François Delalande, Søren Østergaard, Gergő Gógl, A. Cousido-Siah, Alastair G. McEwen, Yushi Men, Farida Salimova, Aurélien Rohrbacher, Camille Kostmann, Yves Nominé, Renaud Vincentelli, Pascal Eberling, Christine Carapito, Gilles Travé, Élodie Monsellier

The paper introduces a high-throughput mass-spectrometry-based assay to measure protein-ligand affinity constants, demonstrating its application to 14-3-3 isoforms and phosphopeptides.

Journal of the American Chemical Society · Mar 25, 2025Peer-reviewedSystems Biology

Quantitative fragmentomics allow affinity mapping of interactomes

Gergő Gógl, Boglárka Zámbó, Camille Kostmann, A. Cousido-Siah, Bastien Morlet, Fabien Durbesson, Luc Négroni, Pascal Eberling, Pau Jané, Yves Nominé, András Zeke, Søren Østergaard, Élodie Monsellier, Renaud Vincentelli, Gilles Travé

The paper measures affinities of 65,000 PDZ domain interactions using quantitative fragmentomics, revealing viral interference hotspots and system-wide impacts of interactome hijacking.

Nature Communications · Sep 17, 2022Peer-reviewedSystems Biology

Rewiring of RSK-PDZ interactions by linear motif phosphorylation

Gergő Gógl, Beáta Biri‐Kovács, Fabien Durbesson, Pau Jané, Yves Nominé, Camille Kostmann, Viktória Bilics, Márton A. Simon, Attila Reményi, Renaud Vincentelli, Gilles Travé, László Nyitray

The paper investigates how phosphorylation of a PDZ-binding linear motif alters interactions with PDZ domains, showing widespread modulation of binding affinities rather than discrete on/off switches.

bioRxiv · Sep 17, 2018 · PreprintSystems Biology