Direct RNA sequencing (RNA004) allows for improved transcriptome assessment and near real-time tracking of methylation for medical applications
Charlotte Hewel, Anna Wierczeiko, Johannes Miedema, Johannes H. Friedrich, Felix Hofmann, Stephan Weißbach, Vincent Dietrich, Laura Holthöfer, Verena Haug, Stefan Mündnich, Lukas Schartel, Lioba Lehmann, Kristi L Jensen, Stefan Diederich, Stanislav Sys, , Susanne Gerber
This study evaluates improvements in direct RNA sequencing (DRS) using RNA004 chemistry and modified-base-calling models, showing enhanced throughput, accuracy, and detection of RNA modifications in clinical applications.
Nucleic Acids Research · Nov 5, 2025Peer-reviewedBioinformatics