Alternative splicing and gene expression repurpose ancestral genes through distinct evolutionary routes
Federica Mantica, Antonio Torres-Méndez, Irene Zapata-Bodalo, L. Iñiguez, Yamile Márquez, Violeta Morin, Jean‐Yves Roignant, Manuel Irimia
The paper compares tissue-specific alternative splicing and gene expression across species to show they follow distinct evolutionary routes in repurposing ancestral genes, with TS-AS playing a key role in nervous system diversification.
bioRxiv · Sep 10, 2026 · PreprintEvolutionary Biology