Antonio Torres-Méndez

Alternative splicing and gene expression repurpose ancestral genes through distinct evolutionary routes

The paper compares tissue-specific alternative splicing and gene expression across species to show they follow distinct evolutionary routes in repurposing ancestral genes, with TS-AS playing a key role in nervous system diversification.

The V-ATPase/ATG16L1 axis is controlled by the V1H subunit

This paper identifies the V1H subunit of V-ATPase as a regulator of ATG16L1 recruitment in response to pH gradient disruption, linking V-ATPase function to autophagy activation.

Evolution of tissue-specific expression of ancestral genes across vertebrates andinsects

The paper investigates the evolution of tissue-specific gene expression across vertebrates and insects, finding that nearly half of ancestral genes have been recruited into tissue-specific transcriptomes.

Insplico: Effective computational tool for studying intron splicing order genome-wide with short and long RNA-seq reads

Insplico quantifies intron splicing order using short and long RNA-seq reads, revealing conserved patterns and novel features across species and tissues.

Parallel evolution of a splicing program controlling neuronal excitability in flies and mammals

The paper identifies a splicing program in neurons of Drosophila and mammals, showing how it evolves independently in different species to regulate ion channels and neuronal activity.

Srrm234, but not canonical SR and hnRNP proteins drive inclusion of Dscam exon 9 variable exons

The paper identifies Srrm234 as a key regulator of Dscam exon 9 alternative splicing, showing that canonical SR and hnRNP proteins have minimal impact on this process.

A rhamnose-inducible system for precise and temporal control of gene expression in cyanobacteria

This paper introduces a rhamnose-inducible promoter system in cyanobacteria with improved properties over existing systems.

An efficient FLP-based toolkit for spatiotemporal control of gene expression in Caenorhabditis elegans

The paper develops an FLP-based toolkit for precise spatiotemporal control of gene expression in C. elegans, achieving high recombination efficiency in specific tissues.