Jean‐Yves Roignant

The paper compares tissue-specific alternative splicing and gene expression across species to show they follow distinct evolutionary routes in repurposing ancestral genes, with TS-AS playing a key role in nervous system diversification.

The paper shows that Pus7 mutations reduce tRNA-Asp levels, activating the integrated stress response and glycolytic reprogramming, which contributes to aggressive behavior.

This study shows that loss of Larp7 or 7SK RNA in Drosophila impairs locomotion and axonal growth, with the 7SK complex regulating transcription of long genes with high GC content promoters.

This study maps 2'-O-methylation sites and identifies C/D box snoRNAs in Drosophila rRNAs, showing limited stress-induced variation in methylation levels.

This paper shows that using high-accuracy nanopore RNA basecalling models improves detection of RNA modifications, read mappability, and basecalling accuracy.

The paper identifies a novel FTSJ1 pathogenic variant and shows its role in neuron morphology and learning performance through RiboMethSeq and transcriptome analysis in human and Drosophila models.

The paper identifies a splicing program in neurons of Drosophila and mammals, showing how it evolves independently in different species to regulate ion channels and neuronal activity.

This study identifies a Barentsz function in neuromuscular synapse growth independent of the exon junction complex, showing its role in mitochondrial distribution and regulation of the Activin ligand Dawdle.

This study shows that m6A RNA methylation regulates RNAP II promoter-proximal pausing, affecting gene expression and transcription.

This study shows that the m6A reader Ythdf limits axonal growth in Drosophila by modulating Fmr1 target selection.

This study shows that Makorin1 promotes oskar translation by displacing Bruno from its 3' UTR, essential for embryonic patterning and germ cell formation in Drosophila.

This study identifies two tRNA methyltransferases in Drosophila that modulate small RNA silencing and lifespan by modifying specific tRNAs.

This study identifies MKRN1 as a key player in ribosome-associated quality control by promoting ribosome stalling at poly(A) sequences to prevent erroneous protein production.

The paper shows that the pre-EJC regulates RNA polymerase II pausing and prevents premature elongation, with consequences for exon skipping and differentiation.

The paper characterizes the complex Lola locus in Drosophila by generating isoform-specific mutations, revealing distinct roles in axon guidance and neurodegeneration via the octopaminergic pathway.