Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains
Samuel C. Agius, Marion Boudes, Evan Healy, Yoona Kim, Yi-Cheng Chang, Melanie Murray, Jan Manent, Jeanette M. J. Rientjes, Zhihao Lai, Sophie Nixon, Jihane Homman‐Ludiye, Vitalina Levina, Edwina McGlinn, Chen Davidovich
The paper shows that PRC2 subunits JARID2 and PALI1 mimic H3K27me3 to restrict Polycomb domain spread by antagonizing PRC2 activity in vivo and stem cells.
Molecular Cell · Mar 1, 2026Peer-reviewedMolecular Biology