Chen Davidovich

The paper shows that PRC2 subunits JARID2 and PALI1 mimic H3K27me3 to restrict Polycomb domain spread by antagonizing PRC2 activity in vivo and stem cells.

The paper determines the structure of tRNA-bound CRISPR-Cas13 and reveals universal HEPN RNase mechanisms for substrate recognition and catalysis.

This study characterizes MORC2 phosphorylation's role in DNA compaction and chromatin remodelling, showing it regulates ATP hydrolysis and DNA binding.

The paper introduces a modular cloning toolkit for constructing multigene vectors compatible with both baculovirus and yeast expression systems.

This study shows that H3.3K9 and K27 modifications regulate repressive chromatin states at cis-regulatory elements and bivalent promoters in mESCs, affecting gene expression.

The paper introduces Mimosa, a Transformer-based model for miRNA target prediction that incorporates non-canonical base-pairing patterns, achieving better performance than traditional methods.

The paper shows that RNase A treatment during ChIP-seq falsely reduces PRC2 chromatin occupancy signals, revealing limitations in using this method to study RNA-dependent chromatin regulation.

This study investigates EZH2 variants linked to Weaver syndrome, showing they cause dominant negative effects on H3K27 methylation, altering chromatin states and contributing to developmental disorders.

The paper introduces CRISPR-ChIP to identify chromatin factors associated with histone modifications in MLL-leukaemia, revealing distinct DOT1L complexes with oncogenic and endogenous functions.