Author

Jan Manent

Australian Regenerative Medicine InstituteORCID 0000-0001-9152-5459Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Edwina McGlinniD· 2 shared Yi-Cheng ChangiD· 2 shared Annita AchilleosiD· 1 shared Chen DavidovichiD· 1 shared Emma L. MooreiD· 1 shared Evan HealyiD· 1 shared Gabriel M. HauswirthiD· 1 shared Jan SchröderiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMolecular Biology

Edwina McGlinnORCID

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2 papers

Recent·Most cited

Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains

Samuel C. Agius, Marion Boudes, Evan Healy, Yoona Kim, Yi-Cheng Chang, Melanie Murray, Jan Manent, Jeanette M. J. Rientjes, Zhihao Lai, Sophie Nixon, Jihane Homman‐Ludiye, Vitalina Levina, Edwina McGlinn, Chen Davidovich

The paper shows that PRC2 subunits JARID2 and PALI1 mimic H3K27me3 to restrict Polycomb domain spread by antagonizing PRC2 activity in vivo and stem cells.

Molecular Cell · Mar 1, 2026Peer-reviewedMolecular Biology

Nr6a1 controls axially-restricted body elongation, segmentation, patterning and lineage allocation

Yi-Cheng Chang, Siew Fen Lisa Wong, Jan Schröder, Gabriel M. Hauswirth, Natalia A. Shylo, Emma L. Moore, Annita Achilleos, Victoria C. Garside, Jose Maria Polo, Jan Manent, Paul A. Trainor, Edwina McGlinn

This study identifies Nr6a1 as a master regulator of trunk-specific axial development in mice, controlling elongation, segmentation, and lineage allocation through Hox gene regulation and gene regulatory networks.

bioRxiv · Mar 21, 2022 · PreprintDevelopmental Biology