Engineering autologous ossicles for the personalized modeling of acute myeloid leukemia
Camille Sauter, Dimitra Zacharaki, Alejandro Garcia Garcia, David Hidalgo Gil, Yuan Li, Ellen Juel Pørtner, Ani Grigoryan, Medea Gabriel, Aurélie Baudet, Sara González Antón, Adam Cohen Simonsen, Jörg Cammenga, Vladimir Lazarevic, Paul Emile Bourgine
This paper introduces OssiGel, a novel engineered matrix that enables the formation of autologous ossicles from AML patient samples, supporting AML cell engraftment and recapitulating patient-specific cellular interactions.
bioRxiv · Jun 2, 2026 · PreprintBioengineering