W. Adams

Streptococcus pneumoniae infection of lung epithelial cells induces internalization of surface GPI-anchored proteins through pneumolysin-mediated activation of host Rho GTPases

This study shows that pneumolysin from Streptococcus pneumoniae causes internalization of GPI-anchored proteins in lung epithelial cells via Rho GTPase activation, reducing cell death and membrane damage.

Pore-forming activity of S. pneumoniae pneumolysin disrupts the paracellular localization of the epithelial adherens junction protein E-cadherin

This study shows that pneumolysin from S. pneumoniae disrupts E-cadherin localization through PLY-dependent and -independent mechanisms, but maximal bacterial translocation requires PLY-dependent neutrophil recruitment.