Trisomy 21 induces pericentrosomal crowding disrupting early stages of primary ciliogenesis and mouse cerebellar development
C. E. Jewett, B. L. McCurdy, E. T. O'Toole, K. S. Given, C. H. Lin, V. Olsen, W. Martin, L. G. Reinholdt, J. M. Espinosa, K. D. Sullivan, W. B. Macklin, R. Prekeris, C. G. Pearson
This study shows that trisomy 21 causes pericentrosomal crowding, disrupting ciliogenesis and leading to neurological deficits in mice.
bioRxiv · Nov 10, 2021Cell Biology