C. E. Jewett

This study shows that increased LBR cholesterol synthase activity in metastatic melanoma leads to nuclear envelope fragility by accumulating cholesterol, promoting NE rupture during cell migration.

This study shows PLK4 is essential for centriole amplification and apical surface area expansion in multiciliated cells, linking these processes in MCCs.

This study shows that trisomy 21 causes pericentrosomal crowding, disrupting ciliogenesis and leading to neurological deficits in mice.

This study shows that increased Pericentrin in trisomy 21 disrupts microtubule networks and mislocalizes centriolar satellites, impairing primary cilia formation.

This study shows that Fip5 and Fip1, Rab11 effectors, are critical for apical microvilli formation in zebrafish intestines, with Fip5 loss leading to microvillus inclusion disease-like phenotypes.