W. Martin

Molecular dynamics simulations reveal molecular mechanisms for the gain and loss of function effects of four SCN2A variants

The paper uses molecular dynamics simulations to analyze four SCN2A variants, revealing how they affect channel structure and function, with R937C being the most unstable.

Trisomy 21 induces pericentrosomal crowding disrupting early stages of primary ciliogenesis and mouse cerebellar development

This study shows that trisomy 21 causes pericentrosomal crowding, disrupting ciliogenesis and leading to neurological deficits in mice.

Micronuclei arising due to loss of KIF18A form stable micronuclear envelopes and do not promote tumorigenesis

This study shows that micronuclei formed due to KIF18A loss form stable envelopes and do not promote tumorigenesis, challenging the idea that all micronuclei contribute to cancer.

Recent invasion of P transposable element into Drosophila yakuba

The paper reports a recent invasion of P-elements into Drosophila yakuba, showing transient frequency changes and absence in sister species, suggesting horizontal gene transfer and hybridization effects.

Mitotic chromosome alignment is required for proper nuclear envelope reassembly

This study shows that mitotic chromosome alignment is necessary for correct nuclear envelope reassembly and cell proliferation, despite being dispensable for maintaining euploidy.

Speed breeding: a powerful tool to accelerate crop research and breeding

This paper introduces speed breeding, a method that accelerates crop research and breeding by shortening generation times and enabling more generations per year.