J. M. Espinosa

Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients, as a function of therapeutic transfusion and hydroxyurea treatment

This study identifies plasma metabolic signatures in sickle cell disease patients linked to cardiorenal dysfunction and treatment response.

Enhanced Effector Activity of Mediator Kinase Module Deficient CAR-T Cells

This study identifies the Mediator kinase module as a regulator of T cell differentiation and shows that its inhibition enhances effector T cell potency.

Trisomy 21 induces pericentrosomal crowding disrupting early stages of primary ciliogenesis and mouse cerebellar development

This study shows that trisomy 21 causes pericentrosomal crowding, disrupting ciliogenesis and leading to neurological deficits in mice.

Trisomy 21 increases microtubules and disrupts centriolar satellite localization

This study shows that increased Pericentrin in trisomy 21 disrupts microtubule networks and mislocalizes centriolar satellites, impairing primary cilia formation.

HERC1 regulates breast cancer cells migration and invasion

This study identifies HERC1 as a regulator of breast cancer cell migration and invasion, showing its potential as a therapeutic target.

USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer

This study identifies USP19 as a regulator of cancer cell migration and invasion, showing its role as a prognostic marker in early breast cancer.

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

This study identifies a mechanism by which Trisomy 21 increases kynurenine pathway activity through overexpression of interferon receptors, leading to immunosuppression and neurotoxicity in Down syndrome.