K. D. Sullivan

Trisomy 21 induces pericentrosomal crowding disrupting early stages of primary ciliogenesis and mouse cerebellar development

This study shows that trisomy 21 causes pericentrosomal crowding, disrupting ciliogenesis and leading to neurological deficits in mice.

Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in Myc-driven Medulloblastoma

This study identifies CDK7 as a therapeutic target in Myc-driven medulloblastoma, showing that its inhibition sensitizes tumors to radiation.

Reciprocal regulation of vacuolar calcium transport and V-ATPase activity, and the effects of Phosphatidylinositol 3,5-bisphosphate

This study shows that Ca2+ and H+ transport across the yeast vacuole membrane are reciprocally regulated and linked to Phosphatidylinositol 3,5-bisphosphate production.

JAK1 inhibition blocks lethal sterile immune responses:implications for COVID-19 therapy

JAK1 inhibition prevents lethal immune responses and organ failure in a mouse model of Down syndrome and viral infection.

Copper Blocks V-ATPase Activity and SNARE Complex Formation to Inhibit Yeast Vacuole Fusion

This study shows that copper inhibits yeast vacuole fusion by blocking SNARE complex formation and V-ATPase activity, with Cu2+ being the active species.

Phosphatidylinositol 3,5-Bisphosphate regulates Ca2+ Transport During Yeast Vacuolar Fusion through Activation of the Ca2+ ATPase Pmc1

This study shows that PI(3,5)P2 regulates Ca2+ transport in yeast vacuoles by activating Pmc1 during fusion, opposing its role in fission.

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

This study identifies a mechanism by which Trisomy 21 increases kynurenine pathway activity through overexpression of interferon receptors, leading to immunosuppression and neurotoxicity in Down syndrome.

Phosphatidylinositol 3,5-Bisphosphate Regulates Yeast Vacuole Fusion at the Transition between trans-SNARE Complex Formation and Hemifusion

This study shows that PI(3,5)P2 inhibits yeast vacuole fusion after SNARE complex formation and during hemifusion, acting as a molecular switch between fission and fusion.