Fc effector activity and neutralization against SARS-CoV-2 BA.4 is compromised in convalescent sera, regardless of the infecting variant
S. Richardson, P. Kgagudi, N. P. Manamela, H. Kaldine, E. Venter, T. Pillay, B. E. Lambson, M. van der Mescht, T. Hermanus, Z. de Beer, T. de Villier, A. Bodenstein, G. van den Berg, M. du Pisanie, W. Burgers, , P. Moore
This study shows that convalescent sera and post-vaccination breakthrough infections have reduced neutralization and ADCC activity against SARS-CoV-2 BA.4, despite prior infection with different variants.
bioRxiv · Jul 14, 2022 · PreprintImmunology