Author

N. P. Manamela

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

P. Kgagudi· 3 shared S. I. Richardson· 3 shared B. E. Lambson· 2 shared I. S. Georgiev· 2 shared L. Morris· 2 shared N. Raju· 2 shared P. L. Moore· 2 shared A. A. Abu-Shmais· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

P. Kgagudi

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Author profile →

4 papers

Recent·Most cited

Development of LIBRA-seq for the Guinea Pig Model System as a Tool for the Evaluation of Antibody Responses to Multivalent HIV-1 Vaccines

M. J. Vukovich, N. Raju, P. Kgagudi, N. P. Manamela, A. A. Abu-Shmais, K. R. Gripenstraw, P. T. Wasdin, S. Shen, B. Dwyer, J. Akoad, R. M. Lynch, D. C. Montefiori, S. I. Richardson, P. L. Moore, I. S. Georgiev

This paper evaluates multivalent HIV-1 Env immunization strategies in guinea pigs and adapts LIBRA-seq for antibody discovery, finding optimal cocktail sizes and identifying public clonotypes.

Journal of Virology · Jan 23, 2024Peer-reviewedImmunology

Enhanced neutralization potency of an identical HIV neutralizing antibody expressed as different isotypes is achieved through genetically distinct mechanisms

T. Moyo-Gwete, C. Scheepers, Z. Makhado, P. Kgagudi, N. B. Mzindle, R. Ziki, S. Madzorera, N. P. Manamela, F. Ayres, B. E. Lambson, S. I. Richardson, L. Morris, P. L. Moore

This study investigates how different isotypes of the same HIV-neutralizing antibody achieve enhanced neutralization potency through distinct mechanisms involving hinge and CH1 regions.

bioRxiv · Aug 17, 2022 · PreprintImmunology

Fc effector activity and neutralization against SARS-CoV-2 BA.4 is compromised in convalescent sera, regardless of the infecting variant

S. Richardson, P. Kgagudi, N. P. Manamela, H. Kaldine, E. Venter, T. Pillay, B. E. Lambson, M. van der Mescht, T. Hermanus, Z. de Beer, T. de Villier, A. Bodenstein, G. van den Berg, M. du Pisanie, W. Burgers, , P. Moore

This study shows that convalescent sera and post-vaccination breakthrough infections have reduced neutralization and ADCC activity against SARS-CoV-2 BA.4, despite prior infection with different variants.

bioRxiv · Jul 14, 2022 · PreprintImmunology

Cross-reactive coronavirus antibodies with diverse epitope specificities and extra-neutralization functions

A. R. Shiakolas, K. J. Kramer, D. Wrapp, S. I. Richardson, A. Schäfer, S. Wall, N. Wang, K. Janowska, K. A. Pilewski, R. Venkat, R. Parks, N. P. Manamela, N. Raju, E. Friedman Fechter, C. M. Holt, , I. S. Georgiev

The paper identifies cross-reactive antibodies against multiple coronaviruses, showing they target diverse epitopes and mediate effector functions.

bioRxiv · Dec 20, 2020 · PreprintImmunology