Author

W. Childers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Approach:comparative / phylogenetic analysis· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

G. Morton· 2 shared D. Kim· 1 shared D. Yang· 1 shared H. Li· 1 shared H. Zhang· 1 shared J. Gordon· 1 shared J. Huang· 1 shared J. Karanicolas· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

G. Morton

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

ZNF251 haploinsufficiency confers PARP inhibitors resistance in BRCA1-mutated cancer cells through activation of homologous recombination

H. Li, S. Chatla, X. Liu, Z. Tian, U. Vekariya, P. Wang, D. Kim, S. Octaviani, Z. Lian, G. Morton, Z. Feng, D. Yang, K. Sullivan-Reed, W. Childers, X. Yu, , J. Huang

This study identifies ZNF251 haploinsufficiency as a mechanism conferring PARP inhibitor resistance in BRCA1-mutated cancer cells through RAD51-mediated homologous recombination.

bioRxiv · Sep 29, 2022 · PreprintCancer Biology

Comparative Modeling of CDK9 Inhibitors to Explore Selectivity and Structure-Activity Relationships

P. Kirubakaran, G. Morton, P. Zhang, H. Zhang, J. Gordon, M. Abou-Gharbia, J.-P. J. Issa, J. Wu, W. Childers, J. Karanicolas

The paper develops a comparative modeling approach to study CDK9 inhibitor selectivity and structure-activity relationships, using existing PDB data and validating with a crystal structure.

bioRxiv · Jun 8, 2020 · PreprintCancer Biology