Author

J.-P. J. Issa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:CITE-seq· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

H. Zhang· 2 shared A. Sun· 1 shared C. Jobin· 1 shared E. Dulaimi· 1 shared G. Morton· 1 shared H. Fung· 1 shared H. Sun· 1 shared J. Gordon· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

H. Zhang

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Microbiota Accelerates Age-Related CpG island Methylation in Colonic Mucosa

A. Sun, L. Cole, S. Maegawa, P. H. Park, K. Keith, J. Madzo, J. Jelinek, C. Jobin, J.-P. J. Issa

The paper shows microbiota accelerates age-related CpG island methylation in colonic mucosa, similar to cancer, and interacts with inflammation to enhance methylation changes.

bioRxiv · Aug 28, 2020 · PreprintMicrobiology

Comparative Modeling of CDK9 Inhibitors to Explore Selectivity and Structure-Activity Relationships

P. Kirubakaran, G. Morton, P. Zhang, H. Zhang, J. Gordon, M. Abou-Gharbia, J.-P. J. Issa, J. Wu, W. Childers, J. Karanicolas

The paper develops a comparative modeling approach to study CDK9 inhibitor selectivity and structure-activity relationships, using existing PDB data and validating with a crystal structure.

bioRxiv · Jun 8, 2020 · PreprintCancer Biology

Engineering of Chimeric Antigen Receptor T Cells with integrin αEβ7 Results in Augmented Therapeutic Efficacy against E-cadherin positive tumor

H. Sun, S. He, L. Meng, Y. Wang, H. Zhang, Y. Liu, J. Wang, M. Tao, S. K. Barta, E. Dulaimi, H. Fung, J.-P. J. Issa, L.-Z. Zheng, Y. Zhang

This study shows that engineering CAR-T cells with CD103 improves their anti-tumor efficacy against E-cadherin positive tumors by enhancing infiltration, expansion, and persistence in vivo.

bioRxiv · Aug 6, 2019 · PreprintImmunology