Z. Tian

Artificial Intelligence Helps to Predict Recurrence and Mortality for Prostate Cancer using Histology Images

This study develops an AI system to predict prostate cancer recurrence using histology images, showing it outperforms existing grading systems in risk categorization.

Ancient DNA in Lycoptera Fossils: Key Discoveries for Evolution and Methodological Reassessment

The paper extracts and analyzes ancient DNA from Lycoptera davidi fossils, identifies original DNA fragments, and introduces a new method for aDNA analysis and a novel genomic mechanism.

Identification of cytokine predominant immunosuppressive class and prognostic risk signatures in glioma

The paper identifies an immunosuppressive class of glioblastoma (IDC) with high anti-inflammatory cytokine expression and poor prognosis, suggesting resistance to immune checkpoint blockade therapy.

Disulfiram Exerts anti-pulmonary Fibrosis Effect by Activating PGE2 Synthesis

This study shows that Disulfiram reduces pulmonary fibrosis by reactivating COX-2-mediated PGE2 synthesis in both cell and animal models.

Widespread readthrough events in plants reveal unprecedented plasticity of stop codons

The paper identifies widespread stop codon readthrough events in plants and reveals the plasticity of stop codons in encoding amino acids.

Development of Fully Human, Bispecific Antibodies that Effectively Block Omicron Variant Pseudovirus Infections

This study develops fully human bispecific antibodies that effectively block Omicron variant pseudovirus infections, showing improved neutralization compared to monoclonal antibodies.

Enhancing Mitochondrial Functions by Optogenetic Clustering

This paper develops an optogenetic method to control mitochondrial clustering and shows it enhances mitochondrial functions.

ZNF251 haploinsufficiency confers PARP inhibitors resistance in BRCA1-mutated cancer cells through activation of homologous recombination

This study identifies ZNF251 haploinsufficiency as a mechanism conferring PARP inhibitor resistance in BRCA1-mutated cancer cells through RAD51-mediated homologous recombination.

Programming super DNA-enzyme molecules for on-demand enzyme activity modulation

This paper develops a super DNA-enzyme molecule (SDEM) that enables on-demand enzyme activity modulation with improved detection limits and reaction rates compared to free enzymes.

Molecular basis for the pheromone-mediated feeding preference of early-instar Mythimna separata larvae

This study identifies MsGOBP2 and MsOR3 as molecular factors mediating Z11-16: Ald-induced host-feeding preference in Mythimna separata larvae.

Multiplex CRISPR strategy targeting viral genome for agriculture and clinical use

This study develops a multiplex CRISPR-Cas system targeting ASF virus genomic loci, demonstrating resistance in gene-edited pigs and potential applications in agriculture and biomedicine.

Bone-Specific Enhancement of Antibody Therapy for Breast Cancer Metastasis to Bone

This paper enhances antibody therapy for breast cancer bone metastasis by engineering antibodies with bone-homing peptides, improving their bone tumor targeting and therapeutic efficacy.

The maize hexokinase gene ZmHXK7 confers salt resistance in transgenic Arabidopsis plants

This study identifies ZmHXK7 as a maize hexokinase gene that improves salt tolerance in transgenic Arabidopsis by enhancing seedling growth and reducing stress inhibition.

Harnessing the Power of Antibodies to Fight Bone Metastasis

This paper develops a bone-targeting antibody using bisphosphonate conjugation and demonstrates its enhanced efficacy against bone metastases in xenograft models.

Kaposi's Sarcoma Herpesvirus Is Associated with Osteosarcoma in Xinjiang Uyghur Population

This study finds a significant association between Kaposi's Sarcoma Herpesvirus (KSHV) infection and osteosarcoma in the Xinjiang Uyghur population, identifying KSHV as a potential risk factor and a newly identified viral-associated cancer.

Insulin Resistance Mediates Crosstalk between Skeletal Muscle and the Heart to Prevent Cardiac Dysfunction

This study shows that insulin resistance in skeletal muscle protects the heart from dysfunction in diet-induced obesity, despite worsening obesity and metabolic syndrome.

Double-transmembrane domain of SNAREs decelerates the fusion by increasing the protein-lipid mismatch

This study shows that double transmembrane domains in SNAREs slow membrane fusion by increasing protein-lipid mismatch, using in vitro experiments and theoretical analysis.

Mechanism of duplex unwinding by coronavirus nsp13 helicases

This paper investigates the unwinding mechanism of coronavirus nsp13 helicases using single-molecule FRET, revealing distinct step sizes and NTP hydrolysis patterns between MERS-CoV and SARS-CoV-2 nsp13.

The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction

This study identifies the Mocln1-calcineurin-TFEB-p62 pathway as mediating cardiac macroautophagy activation due to proteasomal malfunction.

Structure Basis for Inhibition of SARS-CoV-2 by the Feline Drug GC376

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

Global Dynamic Molecular Profiles of Stomatal Lineage Cell Development by Single-Cell RNA Sequencing

The paper uses single-cell RNA sequencing to analyze stomatal lineage cell development in Arabidopsis, identifying new marker genes and transcriptional networks.

Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus

This study identifies aberrant GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe 2019-nCoV patients, linking them to immune damage and mortality.

Novel pelagiphages prevail in the ocean

This study isolates and characterizes ten novel pelagiphages infecting Pelagibacter strains, revealing their genetic diversity, global distribution, and ecological significance.

Separation and detection of minimal length isomeric glycopeptide neoantigen epitopes centering GSTA region of MUC1 by LC-MS

The paper develops a method to detect minimal length isomeric glycopeptide neoantigen epitopes of MUC1 using pronase digestion and LC-MS, distinguishing them by MS/MS patterns and elution profiles.

Quantitative Analysis of Interactive Behavior of Mitochondria and Lysosomes Using Structured Illumination Microscopy

The paper introduces an M-value to quantify mitochondria-lysosome contact and mitophagy using structured illumination microscopy, finding distinct M-value ranges for these processes.

Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore

The paper develops an iridium(III) dye for tracking mitochondrial dynamics under structured illumination microscopy, revealing new insights into mitochondria-lysosome interactions.