Mechanism-based crosslinking probes capture E. coli ketosynthase FabB in conformationally-distinct catalytic states.
A. Chen, J. T. Mindrebo, T. D. Davis, W. E. Kim, Y. Katsuyama, Z. Jiang, Y. Ohnishi, J. P. Noel, M. D. Burkart
The paper solves crystal structures of E. coli FabB in complex with crosslinked ACPs to elucidate its catalytic mechanism and conformational states.
bioRxiv · Apr 4, 2022 · PreprintBiochemistry