Author

Y. Ohnishi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Organism:E. coli· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Y. Katsuyama· 2 shared A. Chen· 1 shared A. Fujii· 1 shared C. Nakashima· 1 shared C.-f. Jiang· 1 shared F. Seifuddin· 1 shared G. L. Lukacs· 1 shared H. Cao· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBioengineering

Y. Katsuyama

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

HERC3 E3 ligase provides an ERAD branch eliminating select membrane proteins

Y. Kamada, Y. Ohnishi, C. Nakashima, A. Fujii, M. Terakawa, I. Hamano, U. Nakayamada, S. Katoh, N. Hirata, H. Tateishi, R. Fukuda, H. Takahashi, G. L. Lukacs, T. Okiyoneda

This study identifies HERC3 as a cytosolic E3 ligase that facilitates ERAD of specific polytopic membrane proteins like CFTR, distinct from RNF5/185.

bioRxiv · Oct 16, 2023 · PreprintCell Biology

Engineering the substrate specificity of toluene degrading enzyme XylM using biosensor XylS and machine learning

Y. Ogawa, Y. Saito, H. Yamaguchi, Y. Katsuyama, Y. Ohnishi

This paper uses a biosensor and machine learning to engineer XylM for improved substrate specificity, achieving 15 times higher productivity than the wild-type.

bioRxiv · Oct 27, 2022Bioengineering

Mechanism-based crosslinking probes capture E. coli ketosynthase FabB in conformationally-distinct catalytic states.

A. Chen, J. T. Mindrebo, T. D. Davis, W. E. Kim, Y. Katsuyama, Z. Jiang, Y. Ohnishi, J. P. Noel, M. D. Burkart

The paper solves crystal structures of E. coli FabB in complex with crosslinked ACPs to elucidate its catalytic mechanism and conformational states.

bioRxiv · Apr 4, 2022 · PreprintBiochemistry

Multilevel integrative transcriptome analyses in humans and humanized mice define in vivo human lncRNA metabolic regulators

X. Ruan, P. Li, Y. Ma, C.-f. Jiang, Y. Chen, Y. Shi, N. Gupta, F. Seifuddin, M. Pirooznia, H. Suemizu, Y. Ohnishi, N. Yoneda, M. Nishiwaki, H. Cao

This study identifies human lncRNA metabolic regulators (hLMRs) using integrative transcriptome analyses and humanized mouse models, validating one hLMR's role in cholesterol metabolism.

bioRxiv · Jan 1, 2020Physiology