A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium
M. J. Ellis, C. N. Tsai, J. W. Johnson, S. French, W. Elhenawy, S. Porwollik, H. Andrews-Polymenis, M. McClelland, J. Magolan, B. K. Coombes, E. D. Brown
The paper identifies antibacterial compounds effective against intracellular Salmonella Typhimurium through macrophage-based screens and shows metergoline enhances activity by perturbing the bacterial outer membrane.
bioRxiv · Aug 2, 2018Microbiology