Author

E. D. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 6

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:bacteria (other)· 3 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Assay:proteomics· 1

Frequent Co-Authors

B. K. Coombes· 2 shared C. MacNair· 2 shared C. N. Tsai· 2 shared J. Magolan· 2 shared L. A. Carfrae· 2 shared S. French· 2 shared B. S. Weber· 1 shared C. Boddy· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

B. K. Coombes

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Screening under infection-relevant conditions reveals chemical sensitivity in multidrug-resistant invasive non-typhoidal Salmonella (iNTS)

C. N. Tsai, M.-A. Massicotte, C. MacNair, J. N. Perry, E. D. Brown, B. K. Coombes

This study identifies chemical sensitivities in multidrug-resistant iNTS Salmonella under infection-relevant conditions, revealing potential drug targets.

bioRxiv · Sep 16, 2022Microbiology

Central metabolism is a key player in E. coli biofilm stimulation by sub-MIC antibiotics

L. N. Yaeger, S. French, E. D. Brown, J.-P. Cote, L. L. Burrows

This study identifies central metabolism and respiration as key drivers of E. coli biofilm formation in response to sub-MIC antibiotics.

bioRxiv · Sep 14, 2022Microbiology

Polynuclear ruthenium complexes are effective antibiotics against Pseudomonas aeruginosa

B. S. Weber, L. A. Carfrae, J. J. Woods, K. Klobucar, N. P. Bigham, C. MacNair, T. Lyn Raivio, J. J. Wilson, E. D. Brown

This study identifies ruthenium complexes as effective antibiotics against Pseudomonas aeruginosa, showing in vivo efficacy and synergy with rifampicin.

bioRxiv · Aug 11, 2022 · PreprintMicrobiology

Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria

P. Labana, M. H. Dornan, M. Lafreniere, T. L. Czarny, E. D. Brown, J. P. Pezacki, C. Boddy

This study identifies armeniaspirol as an antibiotic that inhibits ClpXP and ClpYQ proteases in Gram-positive bacteria, disrupting cell division and showing potential as a new antibiotic class.

bioRxiv · Sep 4, 2020Microbiology

Uncovering the hidden antibiotic potential of Cannabis

M. A. Farha, O. M. El-Halfawy, R. T. Gale, C. R. MacNair, L. A. Carfrae, X. Zhang, N. G. Jentsch, J. Magolan, E. D. Brown

This study investigates the antibacterial properties of cannabinoids, showing efficacy against MRSA and Gram-negative bacteria, and their potential as therapeutic agents.

bioRxiv · Jan 15, 2020Microbiology

A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium

M. J. Ellis, C. N. Tsai, J. W. Johnson, S. French, W. Elhenawy, S. Porwollik, H. Andrews-Polymenis, M. McClelland, J. Magolan, B. K. Coombes, E. D. Brown

The paper identifies antibacterial compounds effective against intracellular Salmonella Typhimurium through macrophage-based screens and shows metergoline enhances activity by perturbing the bacterial outer membrane.

bioRxiv · Aug 2, 2018Microbiology