Oncogenic gene fusions in non-neoplastic precursors as evidence that bacterial infection initiates prostate cancer
E. Shrestha, J. Coulter, W. Guzman, B. Ozbek, L. Mummert, S. Ernst, J. Maynard, A. Meeker, C. Heaphy, M. Haffner, A. M. De Marzo, K. S. Sfanos
This study shows bacterial infections initiate prostate cancer by causing DNA breaks that lead to oncogenic TMPRSS2:ERG fusions in precancerous lesions like PIA.
bioRxiv · Jul 27, 2020Cancer Biology