M. Haffner

Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies

This study shows that acute CDK12 loss in prostate cancer causes HR deficiency via polyadenylation, but chronic loss leads to adaptation, making PARP inhibitors ineffective and suggesting CDK13 targeting as a new therapeutic approach.

Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies

The paper uses single-cell analysis to study how cell surface antigen expression changes in treatment-resistant prostate cancer, revealing transcriptional heterogeneity and shared gene regulatory networks between NEPC and SCLC.

Differential response to LSD1 inhibition in prostate cancer reveals a YAP1 vulnerability in the neuroendocrine subtype

This paper shows that LSD1 inhibition is effective against neuroendocrine prostate cancer (NEPC) and that combining it with YAP/TEAD inhibition enhances treatment efficacy.

The second messenger c-di-AMP controls natural competence via ComFB signaling protein

The paper shows that c-di-AMP regulates natural competence in cyanobacteria via the ComFB signaling protein, which is essential for pilus biogenesis and DNA uptake.

Diurnal rhythm causes metabolic crises in the cyanobacterial mutants of c-di-AMP signalling cascade

The paper investigates the role of c-di-AMP and SbtB in cyanobacterial diurnal metabolism, finding that their disruption leads to metabolic dysregulation and diurnal lethality.

Arrested Agonist Paradigm For Selective Radiosensitization of Prostate Cancer

This paper identifies hydroxyflutamide as an AR arrested agonist that induces DNA damage in prostate cancer cells, enabling selective radiosensitization without promoting growth.

Androgen receptor inhibition induces metabolic reprogramming and increased reliance on oxidative mitochondrial metabolism in prostate cancer

This study shows that androgen receptor inhibition in prostate cancer cells shifts metabolism to oxidative mitochondrial pathways and increases sensitivity to complex I inhibitors.

PII signal transduction superfamily acts as a valve plug to control bicarbonate and ammonia homeostasis among different bacterial phyla

The paper identifies SbtB as a PII-like protein that acts as a unidirectional valve to control bicarbonate transport via SbtA in cyanobacteria, with similar mechanisms observed in Bacillus for ammonium transport.

Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate Cancer

This study identifies two distinct subtypes of neuroendocrine prostate cancer based on neuronal transcription factors and highlights their epigenetic convergence and therapeutic implications.

Oncogenic gene fusions in non-neoplastic precursors as evidence that bacterial infection initiates prostate cancer

This study shows bacterial infections initiate prostate cancer by causing DNA breaks that lead to oncogenic TMPRSS2:ERG fusions in precancerous lesions like PIA.