Author

K. S. Sfanos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cancer & tumor microenvironment· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. M. De Marzo· 4 shared C. E. Joshu· 2 shared E. Shrestha· 2 shared J. Lu· 2 shared J. P. Maynard· 2 shared L. Mummert· 2 shared T. L. Lotan· 2 shared A. J. Korman· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersCancer Biology

A. M. De Marzo

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Author profile →

5 papers

Recent·Most cited

Oncogenic gene fusions in non-neoplastic precursors as evidence that bacterial infection initiates prostate cancer

E. Shrestha, J. Coulter, W. Guzman, B. Ozbek, L. Mummert, S. Ernst, J. Maynard, A. Meeker, C. Heaphy, M. Haffner, A. M. De Marzo, K. S. Sfanos

This study shows bacterial infections initiate prostate cancer by causing DNA breaks that lead to oncogenic TMPRSS2:ERG fusions in precancerous lesions like PIA.

Proceedings of the National Academy of Sciences · Aug 2, 2021Peer-reviewedCancer Biology

P2X4 Purinergic Receptors as a Therapeutic Target in Aggressive Prostate Cancer

J. P. Maynard, J. Lu, I. Vidal, J. Hicks, L. Mummert, T. Ali, R. Kempski, A. M. Carter, R. Sosa, L. B. Peiffer, C. E. Joshu, T. L. Lotan, A. M. De Marzo, K. S. Sfanos

This study identifies P2X4 purinergic receptors as a driver of aggressive prostate cancer and a potential therapeutic target through in vitro and in vivo experiments.

bioRxiv · Jun 4, 2021Cancer Biology

Feasibility of Integrating Canine Olfaction with Chemical and Microbial Profiling of Urine to Detect Lethal Prostate Cancer

C. Guest, R. Harris, K. S. Sfanos, E. Shrestha, A. W. Partin, B. Trock, L. Mangold, R. Bader, A. Kozak, S. Mclean, J. Simons, H. Soule, T. Johnson, W.-Y. Lee, Q. Gao, , A. Mershin

This study tests the feasibility of using canine olfaction, VOC analysis, and microbial profiling in urine to detect lethal prostate cancer, showing 71% sensitivity and 70-76% specificity.

bioRxiv · Sep 9, 2020Cancer Biology

Differential Mast Cell Phenotypes in Benign versus Cancer Tissues and Prostate Cancer Oncologic Outcomes

H. Hempel Sullivan, J. P. Maynard, C. M. Heaphy, J. Lu, A. M. De Marzo, T. L. Lotan, C. E. Joshu, K. S. Sfanos

The paper investigates differential mast cell phenotypes in benign and cancerous prostate tissues and links higher numbers of tryptase-only mast cells to worse oncologic outcomes.

bioRxiv · Jul 23, 2020Cancer Biology

Castration-mediated IL-8 Promotes Myeloid Infiltration and Prostate Cancer Progression

Z. A. Lopez-Bujanda, M. C. Haffner, M. G. Chaimowitz, N. Chowdhury, N. J. Venturini, A. Obradovic, C. S. Hansen, J. Jackow, K. S. Sfanos, C. J. Bieberich, P. J. Hurley, M. J. Selby, A. J. Korman, A. M. Christiano, A. M. De Marzo, C. G. Drake

This study identifies IL-8 secretion from prostate cancer cells during castration as a driver of myeloid infiltration and cancer progression, suggesting targeting IL-8/CXCR2 with immunotherapy could delay castration resistance.

bioRxiv · May 27, 2019Immunology