A. M. De Marzo

Arrested Agonist Paradigm For Selective Radiosensitization of Prostate Cancer

This paper identifies hydroxyflutamide as an AR arrested agonist that induces DNA damage in prostate cancer cells, enabling selective radiosensitization without promoting growth.

Convergent alterations in the tumor microenvironment of MYC-driven human and murine prostate cancer

This study identifies MYC signaling activation as a common driver of tumor microenvironment alterations in human and murine prostate cancer through single-cell RNA-sequencing and comparative analysis.

Progressive spreading of DNA methylation in the GSTP1 promoter CpG island across transitions from precursors to invasive prostate cancer

The paper examines DNA methylation patterns in the GSTP1 promoter across prostate cancer progression stages and finds increasing methylation from normal to cancerous lesions.

Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate

This paper introduces a chromogenic in situ hybridization method to measure telomere lengths in prostate tissues, aiding in the identification of precancerous lesions.

MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression

The paper develops a method to spatially quantify mitochondrial DNA copy number in cancer tissues and finds increased mtDNAcn in prostate cancer progression, linked to MYC activity.

Single-cell atlas of epithelial and stromal cell heterogeneity by lobe and strain in the mouse prostate

The paper constructs a single-cell atlas of mouse prostate cell types across strains and lobes, revealing strain- and lobe-specific transcriptomic differences in epithelial cells and strain-lobespecific fibroblast subtypes.

Oncogenic gene fusions in non-neoplastic precursors as evidence that bacterial infection initiates prostate cancer

This study shows bacterial infections initiate prostate cancer by causing DNA breaks that lead to oncogenic TMPRSS2:ERG fusions in precancerous lesions like PIA.

PHENOTYPIC CHARACTERIZATION OF TWO NOVEL CELL LINE MODELS OF CASTRATION RESISTANT PROSTATE CANCER.

This study develops two novel castration-resistant prostate cancer cell lines and characterizes their transcriptomic and proteomic profiles to understand resistance mechanisms.

P2X4 Purinergic Receptors as a Therapeutic Target in Aggressive Prostate Cancer

This study identifies P2X4 purinergic receptors as a driver of aggressive prostate cancer and a potential therapeutic target through in vitro and in vivo experiments.

Supraphysiological testosterone induces ferroptosis and activates NF-kappaB mediated immune pathways in prostate cancer through nucleophagy

Differential Mast Cell Phenotypes in Benign versus Cancer Tissues and Prostate Cancer Oncologic Outcomes

The paper investigates differential mast cell phenotypes in benign and cancerous prostate tissues and links higher numbers of tryptase-only mast cells to worse oncologic outcomes.

Pervasive promoter hypermethylation of silenced TERT alleles in human cancers

The paper investigates TERT promoter methylation in cancer cells and finds that hypermethylation represses TERT expression, explaining modest telomerase activation in most cancers.

An in situ atlas of mitochondrial DNA in mammalian tissues reveals high content in stem/progenitor cells

The paper creates an in situ atlas of mitochondrial DNA in mammalian tissues, revealing higher mtDNA content in stem/progenitor cells and age-related decreases in renal tubules.

Castration-mediated IL-8 Promotes Myeloid Infiltration and Prostate Cancer Progression

This study identifies IL-8 secretion from prostate cancer cells during castration as a driver of myeloid infiltration and cancer progression, suggesting targeting IL-8/CXCR2 with immunotherapy could delay castration resistance.

Cell-type specific expression of oncogenic and tumor suppressive microRNAs in the human prostate and prostate cancer

The paper quantifies miRNA expression in prostate stroma and epithelium, finding cell-type specific patterns and associations with prostate cancer recurrence.