HIV-1 Envelope and MPER antibody structures in lipid assemblies
K. Rantalainen, Z. T. Berndsen, A. Antanasijevic, T. Schiffner, X. Zhang, W.-H. Lee, J. L. Torres, L. Zhang, A. Irimia, J. Copps, K. Zhou, Y. D. Kwon, W. H. Law, C. A. Schramm, R. Verardi, , A. Ward
This study presents methods to incorporate full-length HIV-1 Env into lipid assemblies for structural analysis, revealing the quaternary epitope of an MPER antibody and Env tilting during neutralization.
bioRxiv · Nov 15, 2019Immunology