J. Auwerx

Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2

This study identifies SIRT2 as a regulator of β-cell proliferation, showing its role in controlling β-cell expansion during hyperglycemia while preserving feedback mechanisms.

Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction

This study shows that reducing CERS1 in skeletal muscle worsens age-related muscle dysfunction in mice and humans, linking it to inflammation and fibrosis.

Induction of mitophagy reverts age-associated decline of the hematopoietic and immune systems

This study shows that inducing mitophagy with Urolithin-A restores hematopoietic and immune system function in aged mice.

Loss-of-SIRT7 sensitizes hepatocellular carcinoma to sorafenib through the regulation of ERK Phosphorylation

This study shows that SIRT7 contributes to sorafenib resistance in HCC by enhancing ERK phosphorylation, and inhibiting SIRT7 with sorafenib reduces tumor growth.

Hepatic lipid overload potentiates biliary epithelial cell activation via E2Fs

This study shows lipid overload activates E2F transcription factors in biliary epithelial cells, driving cell cycle progression and glycolytic metabolism to initiate ductular reaction without epithelial damage.

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

This study shows lysosomes mediate the mitochondrial UPR through mTORC1-dependent ATF4 phosphorylation, essential for mitochondrial redox homeostasis and cell survival under stress.

Inhibition of GCN5 decreases skeletal muscle fat metabolism during high fat diet feeding

This study shows that eliminating GCN5 in skeletal muscle does not improve mitochondrial content or metabolic markers under high-fat diet conditions, but may influence Pdk4 expression and fat metabolism.

A lysosomal surveillance response (LySR) that reduces proteotoxicity and extends healthspan

This paper identifies a lysosomal surveillance response (LySR) that reduces proteotoxicity and extends healthspan in worms and mammalian cells by enhancing protein aggregate clearance.

Reticular Dysgenesis-associated Adenylate Kinase 2 deficiency causes failure of myelopoiesis through disordered purine metabolism

This study shows AK2 deficiency disrupts mitochondrial metabolism, causing purine metabolism disorder and myelopoiesis failure through AMP accumulation and NAD+ depletion.

GCN5 Maintains Muscle Integrity by Acetylating YY1 to Promote Dystrophin Expression

This study shows GCN5 acetylates YY1, reducing its DNA binding and increasing dystrophin expression, which maintains muscle integrity in mice.

PHD3 controls energy homeostasis and exercise capacity.

The paper was submitted in error and the authors do not wish it to be cited.