Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole Genome Sequencing
M.-T. N. Pham, H. Gupta, A. Gupta, A. Vaghasia, A. Skaist, M. A. Garrison, J. B. Coulter, M. C. Haffner, S. J. Wheelan, W. Isaacs, W. Nelson, S. Yegnasubramanian
This study uses linked-read whole genome sequencing to phase mutations and structural variants in prostate cancer cell lines, revealing gene-level haplotypes and complex rearrangements associated with castrate resistance.
bioRxiv · Aug 9, 2021 · PreprintCancer Biology