S. Yegnasubramanian

This paper identifies hydroxyflutamide as an AR arrested agonist that induces DNA damage in prostate cancer cells, enabling selective radiosensitization without promoting growth.

This study identifies MYC signaling activation as a common driver of tumor microenvironment alterations in human and murine prostate cancer through single-cell RNA-sequencing and comparative analysis.

The paper examines DNA methylation patterns in the GSTP1 promoter across prostate cancer progression stages and finds increasing methylation from normal to cancerous lesions.

This study identifies two unique myeloid-derived suppressor cell populations in glioblastoma that promote tumor growth and immune evasion.

The paper develops a method to spatially quantify mitochondrial DNA copy number in cancer tissues and finds increased mtDNAcn in prostate cancer progression, linked to MYC activity.

The paper introduces RepairSwitch, a flow cytometry assay to simultaneously measure HR and NHEJ DNA repair rates in living cells, and demonstrates its utility in assessing drug and genetic perturbations.

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

The paper constructs a single-cell atlas of mouse prostate cell types across strains and lobes, revealing strain- and lobe-specific transcriptomic differences in epithelial cells and strain-lobespecific fibroblast subtypes.

This study shows that TERT promoter hypomethylation and chromatin state differ in neuroblastoma based on telomere maintenance mechanisms, with repressive marks in long telomere-associated cells.

This study uses single-cell RNA sequencing to show BCG vaccination reduces SARS-CoV-2 lung inflammation and disease severity by enhancing antibody production and altering immune cell transcriptional profiles.

This study uses linked-read whole genome sequencing to phase mutations and structural variants in prostate cancer cell lines, revealing gene-level haplotypes and complex rearrangements associated with castrate resistance.

This study develops two novel castration-resistant prostate cancer cell lines and characterizes their transcriptomic and proteomic profiles to understand resistance mechanisms.

The paper uses single-cell RNA-sequencing to show entinostat shifts tumor microenvironment cell states, reducing immunosuppression and enhancing immune checkpoint inhibitor responses in HER2+ breast tumors.

The paper investigates TERT promoter methylation in cancer cells and finds that hypermethylation represses TERT expression, explaining modest telomerase activation in most cancers.

The paper creates an in situ atlas of mitochondrial DNA in mammalian tissues, revealing higher mtDNA content in stem/progenitor cells and age-related decreases in renal tubules.

The paper uses single cell and bulk multi-omics to study early resistance mechanisms in HNSCC cells treated with cetuximab, identifying TFAP2A and EMT as independent pathways.