Author

M.-T. N. Pham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:flow cytometry· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

S. Yegnasubramanian· 3 shared J. B. Coulter· 2 shared M. C. Haffner· 2 shared R. Chikarmane· 2 shared W. G. Nelson· 2 shared A. Archey· 1 shared A. Gupta· 1 shared A. M. De Marzo· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCancer Biology

S. Yegnasubramanian

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3 papers

Recent·Most cited

Arrested Agonist Paradigm For Selective Radiosensitization of Prostate Cancer

J. B. Coulter, M. Haffner, Y. Zhang, H. Zhou, M.-T. N. Pham, J. Chen, R. Chikarmane, A. Mishra, M. S. Mehl, S. Kazibwe, K. Choi, A. Archey, S. Valluri, S. E. Lupold, D. Song, , S. Yegnasubramanian

This paper identifies hydroxyflutamide as an AR arrested agonist that induces DNA damage in prostate cancer cells, enabling selective radiosensitization without promoting growth.

bioRxiv · Oct 1, 2023 · PreprintCancer Biology

RepairSwitch: simultaneous functional assessment of homologous recombination and end joining DNA repair pathways in living cells

R. C. Steinberg, J. Liu, A. M. Vaghasia, H. Giovinazzo, M.-T. N. Pham, D. Tselenchuk, R. Chikarmane, M. C. Haffner, W. G. Nelson, S. Yegnasubramanian

The paper introduces RepairSwitch, a flow cytometry assay to simultaneously measure HR and NHEJ DNA repair rates in living cells, and demonstrates its utility in assessing drug and genetic perturbations.

bioRxiv · Jan 17, 2023 · PreprintCell Biology

Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole Genome Sequencing

M.-T. N. Pham, H. Gupta, A. Gupta, A. Vaghasia, A. Skaist, M. A. Garrison, J. B. Coulter, M. C. Haffner, S. J. Wheelan, W. Isaacs, W. Nelson, S. Yegnasubramanian

This study uses linked-read whole genome sequencing to phase mutations and structural variants in prostate cancer cell lines, revealing gene-level haplotypes and complex rearrangements associated with castrate resistance.

bioRxiv · Aug 9, 2021 · PreprintCancer Biology