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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
11 papers
Recent·Most cited
S. Li, A. Wong, H. Sun, V. Bhatia, G. Javier, S. Jana, R. B. Mongomery, J. L. Wright, H.-M. Lam, A. C. Hsieh, B. M. Faltas, M. C. Haffner, J. K. Lee
This paper introduces a combinatorial genetic strategy to generate diverse cancer models and uses single-cell sequencing to identify polygenic drivers of cancer phenotypes.
bioRxiv · Apr 12, 2023 · PreprintCancer Biology
R. C. Steinberg, J. Liu, A. M. Vaghasia, H. Giovinazzo, M.-T. N. Pham, D. Tselenchuk, R. Chikarmane, M. C. Haffner, W. G. Nelson, S. Yegnasubramanian
The paper introduces RepairSwitch, a flow cytometry assay to simultaneously measure HR and NHEJ DNA repair rates in living cells, and demonstrates its utility in assessing drug and genetic perturbations.
bioRxiv · Jan 17, 2023 · PreprintCell Biology
N. De Sarkar, R. D. Patton, A.-L. Doebley, B. Hanratty, A. J. Kreitzman, J. F. Sarthy, M. Ko, M. Adil, S. Brahma, M. P. Meers, D. H. Janssens, L. S. Ang, I. Coleman, A. Bose, R. F. Dumpit, , G. Ha
This paper identifies nucleosome patterns in ctDNA that distinguish advanced prostate cancer phenotypes, achieving high accuracy in classification using a prediction model.
bioRxiv · Jun 21, 2022Cancer Biology
V. Bhatia, N. V. Kamat, T. E. Pariva, L.-T. Wu, A. Tsao, K. Sasaki, L. T. Wiest, A. Zhang, D. Rudoy, R. Gulati, R. A. Patel, M. P. Roudier, L. D. True, M. C. Haffner, P. S. Nelson, , J. K. Lee
This study develops STEAP1 CAR T cell therapy for advanced prostate cancer, showing potent antitumor activity and safety in preclinical models, but also identifies antigen loss as a resistance mechanism.
bioRxiv · May 16, 2022 · PreprintCancer Biology
S. S. Pattwell, S. Arora, N. Nuechterlein, M. Zager, K. R. Loeb, P. J. Cimino, N. C. Holland, N. Reche-Ley, H. Bolouri, D. A. A. Bonin, F. Szulzewsky, V. V. Phadnis, T. Ozawa, M. J. Wagner, M. C. Haffner, , E. C. Holland
The paper identifies TrkB.T1, an embryonic NTRK2 splice variant, as an oncogenic driver in multiple tumor types across species, with distinct interactors in developmental and oncogenic pathways.
bioRxiv · Jan 7, 2022 · PreprintCancer Biology
S. Zaidi, J. L. Zhao, J. M. Chan, M. P. Roudier, K. M. Wadosky, A. Gopalan, W. R. Karthaus, J. Choi, K. Lawrence, O. Chaudhary, T. Xu, I. Masilionis, L. Mazutis, R. Chaligne, I. Linkov, , C. L. Sawyers
The paper identifies stem-like luminal cells with elevated JAK/STAT signaling as a source of multilineage plasticity in prostate cancer, offering a therapeutic target.
bioRxiv · Nov 1, 2021 · PreprintCancer Biology
M.-T. N. Pham, H. Gupta, A. Gupta, A. Vaghasia, A. Skaist, M. A. Garrison, J. B. Coulter, M. C. Haffner, S. J. Wheelan, W. Isaacs, W. Nelson, S. Yegnasubramanian
This study uses linked-read whole genome sequencing to phase mutations and structural variants in prostate cancer cell lines, revealing gene-level haplotypes and complex rearrangements associated with castrate resistance.
bioRxiv · Aug 9, 2021 · PreprintCancer Biology
M. C. Haffner, A. Bhamidipati, H. K. Tsai, D. M. Esopi, A. M. Vaghasia, J.-Y. Low, R. A. Patel, G. Guner, M.-T. Pham, N. Castagna, J. Hicks, N. Wyhs, R. Aebersold, A. M. De Marzo, W. G. Nelson, , S. Yegnasubramanian
This study develops two novel castration-resistant prostate cancer cell lines and characterizes their transcriptomic and proteomic profiles to understand resistance mechanisms.
bioRxiv · Jul 4, 2021 · PreprintCancer Biology
D. Esopi, M. K. Graham, J. A. Brosnan-Cashman, J. Meyers, A. Vaghasia, A. Gupta, B. Kumar, M. C. Haffner, C. M. Heaphy, A. M. De Marzo, A. K. Meeker, W. Nelson, S. J. Wheelan, S. Yegnasubramanian
The paper investigates TERT promoter methylation in cancer cells and finds that hypermethylation represses TERT expression, explaining modest telomerase activation in most cancers.
bioRxiv · Jan 29, 2020Cancer Biology
J. Chen, Q. Zheng, L. B. Peiffer, J. L. Hicks, M. C. Haffner, A. Z. Rosenberg, M. Levi, X. X. Wang, B. Ozbek, S. Yegnasubramanian, A. M. De Marzo
The paper creates an in situ atlas of mitochondrial DNA in mammalian tissues, revealing higher mtDNA content in stem/progenitor cells and age-related decreases in renal tubules.
bioRxiv · Dec 19, 2019Pathology
Z. A. Lopez-Bujanda, M. C. Haffner, M. G. Chaimowitz, N. Chowdhury, N. J. Venturini, A. Obradovic, C. S. Hansen, J. Jackow, K. S. Sfanos, C. J. Bieberich, P. J. Hurley, M. J. Selby, A. J. Korman, A. M. Christiano, A. M. De Marzo, C. G. Drake
This study identifies IL-8 secretion from prostate cancer cells during castration as a driver of myeloid infiltration and cancer progression, suggesting targeting IL-8/CXCR2 with immunotherapy could delay castration resistance.
bioRxiv · May 27, 2019Immunology