Author

A. Vaghasia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

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Organism:human· 4 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. Gupta· 4 shared S. Yegnasubramanian· 4 shared A. M. De Marzo· 3 shared W. Nelson· 3 shared A. Skaist· 2 shared J. Meyers· 2 shared M. C. Haffner· 2 shared M. K. Graham· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersCancer Biology

A. Gupta

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4 papers

Recent·Most cited

Convergent alterations in the tumor microenvironment of MYC-driven human and murine prostate cancer

M. K. Graham, R. Wang, R. Chikarmane, B. Wodu, A. Vaghasia, A. Gupta, Q. Zheng, J. Hicks, P. Sysa-Shah, X. Pan, N. Castagna, J. Liu, J. Meyers, A. Skaist, Y. Zhang, , S. Yegnasubramanian

This study identifies MYC signaling activation as a common driver of tumor microenvironment alterations in human and murine prostate cancer through single-cell RNA-sequencing and comparative analysis.

bioRxiv · Sep 7, 2023Cancer Biology

MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression

J. Chen, Q. Zheng, J. L. Hicks, L. Trabzonlu, B. Ozbek, T. Jones, A. Vaghasia, T. C. Larman, R. Wang, M. C. Markowski, S. R. Denmeade, K. J. Pienta, R. H. Hruban, E. S. Antonarakis, A. Gupta, , A. M. De Marzo

The paper develops a method to spatially quantify mitochondrial DNA copy number in cancer tissues and finds increased mtDNAcn in prostate cancer progression, linked to MYC activity.

bioRxiv · Feb 20, 2023Cancer Biology

Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole Genome Sequencing

M.-T. N. Pham, H. Gupta, A. Gupta, A. Vaghasia, A. Skaist, M. A. Garrison, J. B. Coulter, M. C. Haffner, S. J. Wheelan, W. Isaacs, W. Nelson, S. Yegnasubramanian

This study uses linked-read whole genome sequencing to phase mutations and structural variants in prostate cancer cell lines, revealing gene-level haplotypes and complex rearrangements associated with castrate resistance.

bioRxiv · Aug 9, 2021 · PreprintCancer Biology

Pervasive promoter hypermethylation of silenced TERT alleles in human cancers

D. Esopi, M. K. Graham, J. A. Brosnan-Cashman, J. Meyers, A. Vaghasia, A. Gupta, B. Kumar, M. C. Haffner, C. M. Heaphy, A. M. De Marzo, A. K. Meeker, W. Nelson, S. J. Wheelan, S. Yegnasubramanian

The paper investigates TERT promoter methylation in cancer cells and finds that hypermethylation represses TERT expression, explaining modest telomerase activation in most cancers.

bioRxiv · Jan 29, 2020Cancer Biology