Author

S. J. Wheelan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 3 Cell Biology· 1

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Approach:statistical model· 4 Organism:human· 3 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:mouse· 1

Frequent Co-Authors

A. Gupta· 3 shared A. Skaist· 3 shared S. Yegnasubramanian· 3 shared W. Nelson· 3 shared A. M. De Marzo· 2 shared A. Vaghasia· 2 shared J. Meyers· 2 shared M. C. Haffner· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersCancer Biology

A. Gupta

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Author profile →

4 papers

Recent·Most cited

Islands of genomic stability in the face of genetically unstable metastatic cancer

K. Bowland, J. Lai, A. Skaist, Y. Zhang, S. S. K. Teh, N. J. Roberts, E. Thompson, S. J. Wheelan, R. H. Hruban, R. Karchin, C. A. Iacobuzio-Donahue, J. R. Eshleman

The paper identifies genomically stable regions in metastatic pancreatic cancer that can be targeted by CRISPR-Cas9 due to preserved PAM sites, suggesting a potential gene therapy approach.

bioRxiv · Jan 26, 2024Cancer Biology

Single-cell atlas of epithelial and stromal cell heterogeneity by lobe and strain in the mouse prostate

M. K. Graham, R. Chikarmane, R. Wang, A. M. Vaghasia, A. Gupta, Q. Zheng, B. P. Wodu, X. Pan, N. Castagna, J. Liu, J. Meyers, A. Skaist, S. J. Wheelan, B. W. Simons, C. Bieberich, , S. Yegnasubramanian

The paper constructs a single-cell atlas of mouse prostate cell types across strains and lobes, revealing strain- and lobe-specific transcriptomic differences in epithelial cells and strain-lobespecific fibroblast subtypes.

bioRxiv · Jan 31, 2022Cell Biology

Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole Genome Sequencing

M.-T. N. Pham, H. Gupta, A. Gupta, A. Vaghasia, A. Skaist, M. A. Garrison, J. B. Coulter, M. C. Haffner, S. J. Wheelan, W. Isaacs, W. Nelson, S. Yegnasubramanian

This study uses linked-read whole genome sequencing to phase mutations and structural variants in prostate cancer cell lines, revealing gene-level haplotypes and complex rearrangements associated with castrate resistance.

bioRxiv · Aug 9, 2021 · PreprintCancer Biology

Pervasive promoter hypermethylation of silenced TERT alleles in human cancers

D. Esopi, M. K. Graham, J. A. Brosnan-Cashman, J. Meyers, A. Vaghasia, A. Gupta, B. Kumar, M. C. Haffner, C. M. Heaphy, A. M. De Marzo, A. K. Meeker, W. Nelson, S. J. Wheelan, S. Yegnasubramanian

The paper investigates TERT promoter methylation in cancer cells and finds that hypermethylation represses TERT expression, explaining modest telomerase activation in most cancers.

bioRxiv · Jan 29, 2020Cancer Biology