Author

W. M. Shafer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

C. Rouquette-Loughlin· 2 shared J. L. Reimche· 2 shared V. Dhulipala· 2 shared A. Begum· 1 shared A. E. Jerse· 1 shared A. J. Abrams· 1 shared C. Pham· 1 shared Cyr, S. St· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersMicrobiology

C. Rouquette-Loughlin

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3 papers

Recent·Most cited

Hormonal steroids bind the Neisseria gonorrhoeae multidrug resistance regulator, MtrR, to induce a multidrug binding efflux pump and stress-response sigma factor

G. Hooks, J. Ayala, G. Beggs, J. R. Perfect, M. Schumacher, W. M. Shafer, R. G. Brennan

This study identifies hormonal steroids that bind MtrR, a regulator in Neisseria gonorrhoeae, leading to reduced DNA binding and activation of multidrug efflux pumps and stress-response mechanisms.

bioRxiv · Jun 13, 2023 · PreprintBiochemistry

Mechanistic basis for decreased antimicrobial susceptibility in a clinical isolate of Neisseria gonorrhoeae possessing a mosaic-like mtr efflux pump locus

C. Rouquette-Loughlin, J. L. Reimche, J. T. Balthazar, V. Dhulipala, K. Gernert, E. Kersh, C. Pham, K. Pettus, A. J. Abrams, D. L. Trees, Cyr, S. St, W. M. Shafer

The paper investigates how a mosaic-like mtr efflux pump locus in Neisseria gonorrhoeae reduces antimicrobial susceptibility through promoter mutations and amino acid changes in MtrD.

bioRxiv · Oct 22, 2018Microbiology

Cis- and trans-acting factors influence expression of the norM-encoded efflux pump of Neisseria gonorrhoeae and levels of gonococcal susceptibility to substrate antimicrobials

C. Rouquette-Loughlin, V. Dhulipala, J. L. Reimche, E. Raterman, A. Begum, A. E. Jerse, W. M. Shafer

This study identifies cis- and trans-acting factors regulating the norM efflux pump in Neisseria gonorrhoeae and their impact on antimicrobial susceptibility.

bioRxiv · Apr 25, 2018Microbiology