Author

J. R. Perfect

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Organism:fungi (other)· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

A. Casadevall· 2 shared J. Tenor· 2 shared R. G. Brennan· 2 shared A. Alanio· 1 shared A. Bartesaghi· 1 shared A. Brockway· 1 shared A. L. Hsu· 1 shared A. Sturny-Leclere· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersMicrobiology

A. Casadevall

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Hormonal steroids bind the Neisseria gonorrhoeae multidrug resistance regulator, MtrR, to induce a multidrug binding efflux pump and stress-response sigma factor

G. Hooks, J. Ayala, G. Beggs, J. R. Perfect, M. Schumacher, W. M. Shafer, R. G. Brennan

This study identifies hormonal steroids that bind MtrR, a regulator in Neisseria gonorrhoeae, leading to reduced DNA binding and activation of multidrug efflux pumps and stress-response mechanisms.

bioRxiv · Jun 13, 2023 · PreprintBiochemistry

Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans: a target for novel antifungals

E. J. Washington, Y. Zhou, A. L. Hsu, M. Petrovich, J. L. Tenor, D. L. Toffaletti, Z. Guan, J. R. Perfect, M. J. Borgnia, A. Bartesaghi, R. G. Brennan

This paper reports the cryo-EM structures of CnTps1 from Cryptococcus neoformans in unliganded and ligand-bound forms, revealing substrate-binding residues and tetramer stabilization, with implications for antifungal drug design.

bioRxiv · Mar 14, 2023 · PreprintBiochemistry

Amoeba predation of Cryptococcus neoformans results in pleiotropic changes to traits associated with virulence

M. S. Fu, L. C. Liporagi-Lopes, S. R. dos Santos Junior, J. Tenor, J. R. Perfect, C. Cuomo, A. Casadevall

This study shows that prolonged exposure of Cryptococcus neoformans to amoebae leads to pleiotropic phenotypic and genetic changes that enhance resistance to predation and macrophage toxicity.

bioRxiv · Aug 7, 2020Microbiology

Assessing the virulence of Cryptococcus neoformans causing meningitis in HIV infected and uninfected patients in Vietnam

T. T. Lam, D. Toffaletti, J. Tenor, C. Giamberardino, G. Sempowski, Y. Asfaw, T. H. Phan, A. V. Duong, T. M. Nguyen, L. P. H. Nguyen, C. T. H. Tran, P. M. Ashton, J. Beardsley, C. V. V. Nguyen, G. E. Thwaites, , J. N. Day

This study compares the virulence of Cryptococcus neoformans ST5 and non-ST5 isolates in HIV-infected and uninfected patients in Vietnam, finding ST5 isolates show greater variability and initial inflammatory response but lower fungal burden in mice.

bioRxiv · Feb 19, 2020Microbiology

Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype

B. Hommel, A. Sturny-Leclere, S. Volant, N. Veluppillai, M. Duchateau, C.-H. Yu, V. Hourdel, H. Varet, M. Matondo, J. R. Perfect, A. Casadevall, F. Dromer, A. Alanio

This paper demonstrates that Cryptococcus neoformans can enter a viable but non-culturable state under specific in vitro conditions, characterized by reduced metabolism and reactivation potential.

bioRxiv · Jun 29, 2019Microbiology

Phenotypic variability correlates with clinical outcome in Cryptococcus isolates obtained from Botswanan HIV/AIDS patients

D. A. Carter, K. E. Fernandes, A. Brockway, M. Haverkamp, C. A. Cuomo, F. Van Ogtrop, J. R. Perfect

The paper examines Cryptococcus isolates from HIV/AIDS patients in Botswana, finding that phenotypic variability correlates with clinical outcomes, with 'large' and 'small' phenotypes linked to different disease symptoms and patient mortality.

bioRxiv · Sep 16, 2018Microbiology