Author

R. G. Brennan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 1 Organism:fungi (other)· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

J. R. Perfect· 2 shared A. Bartesaghi· 1 shared A. L. Hsu· 1 shared A. Turdiev· 1 shared B. W. Anderson· 1 shared D. L. Toffaletti· 1 shared E. J. Washington· 1 shared G. Beggs· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

J. R. Perfect

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Author profile →

3 papers

Recent·Most cited

Hormonal steroids bind the Neisseria gonorrhoeae multidrug resistance regulator, MtrR, to induce a multidrug binding efflux pump and stress-response sigma factor

G. Hooks, J. Ayala, G. Beggs, J. R. Perfect, M. Schumacher, W. M. Shafer, R. G. Brennan

This study identifies hormonal steroids that bind MtrR, a regulator in Neisseria gonorrhoeae, leading to reduced DNA binding and activation of multidrug efflux pumps and stress-response mechanisms.

bioRxiv · Jun 13, 2023 · PreprintBiochemistry

Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans: a target for novel antifungals

E. J. Washington, Y. Zhou, A. L. Hsu, M. Petrovich, J. L. Tenor, D. L. Toffaletti, Z. Guan, J. R. Perfect, M. J. Borgnia, A. Bartesaghi, R. G. Brennan

This paper reports the cryo-EM structures of CnTps1 from Cryptococcus neoformans in unliganded and ligand-bound forms, revealing substrate-binding residues and tetramer stabilization, with implications for antifungal drug design.

bioRxiv · Mar 14, 2023 · PreprintBiochemistry

The nucleotide messenger (p)ppGpp is a co-repressor of the purine synthesis transcription regulator PurR in Firmicutes

B. W. Anderson, M. A. Schumacher, J. Yang, A. Turdiev, H. Turdiev, Q. He, V. T. Lee, R. G. Brennan, J. D. Wang

This study shows (p)ppGpp acts as a co-repressor of PurR in Firmicutes, downregulating purine synthesis by enhancing PurR DNA binding, with implications across environments from the gut to pathogens.

bioRxiv · Dec 2, 2020 · PreprintMicrobiology