MYC regulates ribosome biogenesis and mitochondrial gene expression programs through interaction with Host Cell Factor-1
T. M. Popay, J. Wang, C. M. Adams, S. G. Codreanu, S. D. Sherrod, J. A. McLean, L. R. Thomas, S. L. Lorey, Y. J. Machida, A. M. Weissmiller, C. M. Eischen, Q. Liu, W. Tansey
This study identifies HCF-1 as a critical co-factor for MYC in driving mitochondrial and ribosome biogenesis gene expression, and shows its impact on cell growth and tumor progression.
bioRxiv · Jun 22, 2020Cancer Biology