Inhibition of SARS-CoV-2 viral entry in vitro upon blocking N- and O-glycan elaboration
Q. Yang, T. A. Hughes, A. Kelkar, X. Yu, K. Cheng, S. J. Park, W.-C. Huang, J. F. Lovell, S. Neelamegham
This study shows that blocking N- and O-glycan biosynthesis reduces SARS-CoV-2 viral entry by affecting Spike protein proteolysis and RBD presentation.
bioRxiv · Oct 15, 2020Biochemistry