Author

S. Neelamegham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

K. Cheng· 2 shared S. M. Haslam· 2 shared X. Yu· 2 shared A. Addhya· 1 shared A. Antonopoulos· 1 shared A. Chernykh· 1 shared A. Dell· 1 shared A. E. Friedman· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

K. Cheng

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Knockout studies using CD34+ hematopoietic cells suggest that CD44 is a physiological human neutrophil E-selectin ligand

Y. Zhu, S. Neelamegham

This study identifies CD44 as a physiological E-selectin ligand on human neutrophils using CRISPR/Cas9 gene-editing and microfluidics-based assays.

bioRxiv · Aug 18, 2023 · PreprintImmunology

Avian and Human Influenza Viruses Exhibit Distinct Glycoconjugate Receptor Specificities in Human Lung Cells

C.-Y. Liang, I. Huang, J. Han, S. Manivasagam, J. Plung, M. Sturtz, Y. Yu, M. Kandasamy, F. A. Gourronc, A. J. Klingelhutz, B. Choudhury, L. Rong, J. T. Perez, S. Neelamegham, B. Manicassamy

The paper shows human and avian influenza viruses use different glycoconjugate types for infection, with avian strains using a broader range.

bioRxiv · Jun 29, 2022Microbiology

Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Serum N- and O-Glycopeptide Data

R. Kawahara, A. Chernykh, K. Alagesan, M. Bern, W. Cao, R. J. Chalkley, K. Cheng, M. S. Choo, N. Edwards, R. Goldman, M. Hoffmann, Y. Hu, Y. Huang, J. Y. Kim, D. Kletter, , Palmisano

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

bioRxiv · Mar 14, 2021 · PreprintBiochemistry

Efficient Inhibition of O-glycan biosynthesis using the hexosamine analog Ac5GalNTGc

S.-S. Wang, V. del Solar, X. Yu, A. Antonopoulos, A. E. Friedman, K. Agarwal, M. Garg, S. M. Ahmed, A. Addhya, M. Nasirikenari, J. T. Lau, A. Dell, S. M. Haslam, S.-G. Sampathkumar, S. Neelamegham

This paper demonstrates that Ac5GalNTGc is a potent inhibitor of O-glycan biosynthesis, effectively reducing O-glycan elongation and modulating leukocyte functions.

bioRxiv · Dec 13, 2020Biochemistry

Inhibition of SARS-CoV-2 viral entry in vitro upon blocking N- and O-glycan elaboration

Q. Yang, T. A. Hughes, A. Kelkar, X. Yu, K. Cheng, S. J. Park, W.-C. Huang, J. F. Lovell, S. Neelamegham

This study shows that blocking N- and O-glycan biosynthesis reduces SARS-CoV-2 viral entry by affecting Spike protein proteolysis and RBD presentation.

bioRxiv · Oct 15, 2020Biochemistry