Author

T. A. Hughes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1

Frequent Co-Authors

J. L. Thorne· 3 shared A. Websdale· 2 shared G. Cioccoloni· 2 shared H. Roberg-Larsen· 2 shared J. B. Moore· 2 shared P. Lianto· 2 shared A. Kelkar· 1 shared A. Rose· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

J. L. Thorne

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pharmacologic and genetic inhibition of cholesterol esterification reduces tumour burden: a pan-cancer systematic review and meta-analysis of preclinical models

A. Websdale, Y. Kiew, P. Chalmers, X. Chen, G. Cioccoloni, T. A. Hughes, X. Luo, R. Mwarazi, M. Poirot, H. Roberg-Larsen, R. Wu, M. Xu, M. A. Zulyniak, J. L. Thorne

This paper reviews preclinical studies showing that inhibiting cholesterol esterification reduces tumour burden across cancers, with SOAT inhibitors like avasimibe showing promise.

bioRxiv · Jun 12, 2021Cancer Biology

Comprehensive profiling of liver x receptor splicing in triple negative breast cancer reveals existence of novel splice variants that are prognostic for survival

P. Lianto, J. B. Moore, T. A. Hughes, J. L. Thorne

The paper identifies novel LXR splice variants in triple negative breast cancer and shows their prognostic significance for patient survival.

bioRxiv · Jun 9, 2021 · PreprintCancer Biology

Inhibition of SARS-CoV-2 viral entry in vitro upon blocking N- and O-glycan elaboration

Q. Yang, T. A. Hughes, A. Kelkar, X. Yu, K. Cheng, S. J. Park, W.-C. Huang, J. F. Lovell, S. Neelamegham

This study shows that blocking N- and O-glycan biosynthesis reduces SARS-CoV-2 viral entry by affecting Spike protein proteolysis and RBD presentation.

bioRxiv · Oct 15, 2020Biochemistry

Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer

S. A. Hutchinson, A. Websdale, P. Lianto, G. Cioccoloni, H. Roberg-Larsen, B. Kim, A. Rose, C. Soteriou, L. M. Wastall, B. Williams, M. Henn, J. J. Chen, L. Ma, J. B. Moore, E. R. Nelson, , J. L. Thorne

This study identifies LXRalpha as a driver of chemoresistance in TNBC through its regulation of P-glycoprotein, linking cholesterol metabolism to chemotherapy failure.

bioRxiv · Aug 4, 2020Cancer Biology