Author

W.-H. Liu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1

Frequent Co-Authors

I. Jeremias· 3 shared M. Carlet· 3 shared T. Herold· 2 shared A. Arner· 1 shared A.-K. Wirth· 1 shared B. Fehse· 1 shared B. Vick· 1 shared C. D. Baldus· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

I. Jeremias

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3 papers

Recent·Most cited

In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets

M. Carlet, K. Voelse, J. Vergalli, M. Becker, T. Herold, A. Arner, W.-H. Liu, V. Dill, B. Fehse, C. D. Baldus, L. Bastian, L. Lenk, D. M. Schewe, J. W. Bagnoli, P. J. Jost, , I. Jeremias

The paper develops an in vivo inducible RNAi system in patient-derived xenograft models to identify therapeutic targets in acute leukemias.

bioRxiv · May 2, 2020Cancer Biology

Inducible transgene expression in PDX models in vivo identifies KLF4 as therapeutic target for B-ALL

W.-H. Liu, P. Mrozek-Gorska, T. Herold, L. Schwarzkopf, D. Pich, K. Völse, A.-K. Wirth, M. C. Melo-Narvaez, M. Carlet, W. Hammerschmidt, I. Jeremias

The paper uses PDX models to show KLF4 re-expression reduces B-ALL leukemia load and sensitizes tumors to chemotherapy, suggesting Azacitidine could regulate KLF4 as a therapeutic option.

bioRxiv · Mar 6, 2020Cancer Biology

Functional plasticity and reversible growth behavior of patients acute myeloid leukemia stem cells growing in mice

S. Ebinger, C. Zeller, M. Carlet, D. Senft, W.-H. Liu, M. Rothenberg-Thurley, K. H. Metzeler, K. Spiekermann, B. Vick, I. Jeremias

This study shows AML stem cells can switch between low-cycling, treatment-resistant and actively proliferating states in mice, suggesting functional plasticity that could be targeted therapeutically.

bioRxiv · Jul 19, 2019 · PreprintCancer Biology