M. C. Melo-Narvaez

Primary human lung fibroblasts exhibit trigger- but not disease-specific cellular senescence and impair alveolar epithelial cell progenitor function

This study shows that primary human lung fibroblasts from different disease origins exhibit similar susceptibility to senescence induction but distinct senescent programs, which impair alveolar epithelial progenitor function.

Inducible transgene expression in PDX models in vivo identifies KLF4 as therapeutic target for B-ALL

The paper uses PDX models to show KLF4 re-expression reduces B-ALL leukemia load and sensitizes tumors to chemotherapy, suggesting Azacitidine could regulate KLF4 as a therapeutic option.